Development balances cell growth and death.
- Nobel Prize
- Sydney Brenner, H. Robert Horvitz and John E. Sulston were awarded the Nobel Prize for their work on genetic regulation of organ development and programmed cell death.
- WormClassroom is an education portal for the research model organism Caenorhabditis elegans with information on research and instructional materials.
- A prototype, this web site will eventually contain all the sequences from the worm genome. It will be searchable and cross-referenced to mutations and known expression patterns.
- BioWeb, 1999, A Conversation/Lab Tour with H. Robert Horvitz, Harcourt College Publishers.
- Clarke, A.R., et al., 1993, Thymocyte apoptosis induced by p53-dependent and independent pathways, Nature, 362: 849-852.
- Elledge, S.J., 1996, Cell Cycle Checkpoints: Preventing an Identity Crisis, Science, 274: 1664-1672.
- Hartwell, L.H. and Kastan, M.B., 1994, Cell Cycle Control and Cancer, Science, 266: 1821-1828.
- Hartwell, L.H. and Weinert, T.A., 1989, Checkpoints: Controls That Ensure the Order of Cell Cycle Events, Science, 246: 629-634.
- Hengartner, M.O. and Horvitz, H.R., 1994, C. elegans Cell Survival Gene ced-9 Encodes a Functional Homolog of the Mammalian Proto-Oncogene bcl-2, Cell, 76: 665-676.
- Hengartner, M.O. and Horvitz, H.R., 1994, Programmed Cell Death in Caenorhabditis elegans, Current Opinion in Genetics and Development, 4: 581-586.
- Lowe, S.W., Jacks, T., Housman, D.E., Ruley, H.E., 1994, Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells, Proc. Natl. Acad. Sci., 91: 2026-2030.
- Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A. and Jacks, T., 1993, p53 is required for radiation-induced apoptosis in mouse thymocytes, Nature, 362: 847-849.
- Murray, A., 1994, Cell Cycle Checkpoints, Current Opinion in Cell Biology, 6: 872-876.
- Spector, M.S., Desnoyers, S., Hoeppner, D.J., Hengartner, M.O., 1997, Interaction between the C. elegans cell-death regulators CED-9 and CED-4, Nature, 385: 653-656.
- Xue, D. and Horvitz, H.R., 1997, Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor, Nature, 390: 305-308.