Concept 24 The RNA message is sometimes edited.
Rich Roberts is Director of Research for New England Biolabs, one of the first commercial sources for restriction enzymes that is today a leading supplier of molecular biology reagents.
Phil Sharp is the Salvador E. Luria Professor of Biology at the Massachusetts Institute of Technology. His laboratory studies both the catalytic processes responsible for splicing and the nature of the factors conferring specificity.
- Go to:
- Richard Roberts
Phil Sharp
- Recounting how he came to Cold Spring Harbor Laboratory to study viruses.
- Describing long nuclear versus short cytoplasmic message RNA, and what the differences suggested.
- Interpreting the electron micrographs that led to the discovery of the split gene.
- Developing the experimental technologies used to study DNA fragments: agarose gel electrophoresis and restriction enzymes.
- Commenting on how the real excitement of science comes when you don't know what's going on, and you get to be part of 'the chase.'
DNA and proteins are key molecules of the cell nucleus.
One gene makes one protein.
A gene is made of DNA.
Bacteria and viruses have DNA too.
The DNA molecule is shaped like a twisted ladder.
A half DNA ladder is a template for copying the whole.
RNA is an intermediary between DNA and protein.
DNA words are three letters long.
A gene is a discrete sequence of DNA nucleotides.
The RNA message is sometimes edited.
Some viruses store genetic information in RNA.
RNA was the first genetic molecule.
Mutations are changes in genetic information.
Some types of mutations are automatically repaired.