Concept 38 Development balances cell growth and death.

Links

Nobel Prize

Sydney Brenner, H. Robert Horvitz and John E. Sulston were awarded the Nobel Prize for their work on genetic regulation of organ development and programmed cell death.

WormClassroom

WormClassroom is an education portal for the research model organism Caenorhabditis elegans with information on research and instructional materials.

WormBase

A prototype, this web site will eventually contain all the sequences from the worm genome. It will be searchable and cross-referenced to mutations and known expression patterns.

Bibliography

• BioWeb, 1999, A Conversation/Lab Tour with H. Robert Horvitz, Harcourt College Publishers.
• Clarke, A.R., et al., 1993, Thymocyte apoptosis induced by p53-dependent and independent pathways, Nature, 362: 849-852.
• Elledge, S.J., 1996, Cell Cycle Checkpoints: Preventing an Identity Crisis, Science, 274: 1664-1672.
• Hartwell, L.H. and Kastan, M.B., 1994, Cell Cycle Control and Cancer, Science, 266: 1821-1828.
• Hartwell, L.H. and Weinert, T.A., 1989, Checkpoints: Controls That Ensure the Order of Cell Cycle Events, Science, 246: 629-634.
• Hengartner, M.O. and Horvitz, H.R., 1994, C. elegans Cell Survival Gene ced-9 Encodes a Functional Homolog of the Mammalian Proto-Oncogene bcl-2, Cell, 76: 665-676.
• Hengartner, M.O. and Horvitz, H.R., 1994, Programmed Cell Death in Caenorhabditis elegans, Current Opinion in Genetics and Development, 4: 581-586.
• Lowe, S.W., Jacks, T., Housman, D.E., Ruley, H.E., 1994, Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells, Proc. Natl. Acad. Sci., 91: 2026-2030.
• Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A. and Jacks, T., 1993, p53 is required for radiation-induced apoptosis in mouse thymocytes, Nature, 362: 847-849.
• Murray, A., 1994, Cell Cycle Checkpoints, Current Opinion in Cell Biology, 6: 872-876.
• Spector, M.S., Desnoyers, S., Hoeppner, D.J., Hengartner, M.O., 1997, Interaction between the C. elegans cell-death regulators CED-9 and CED-4, Nature, 385: 653-656.
• Xue, D. and Horvitz, H.R., 1997, Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor, Nature, 390: 305-308.