Concept 40 Living things share common genes.

Links

The Bacterial ID Lab

Pick the virtual bacterial ID lab link. This virtual lab takes you to the bench of a sequencing lab where you go through all the steps in sequencing bacterial DNA. Then you search BLAST to find and identify the source of the DNA. (HINT: To copy the sequence during the lab, press 'control' and 'c' simultaneously.)

Molecular Biology and Primate Phylogenetics

This link from the Woodrow Wilson National Fellowship Foundation is a lab protocol for teachers. The lab uses homologous sequences in primates to uncover the evolutionary relationships with our cousins.

Bibliography

• Angier, N., 1988, Natural Obsessions: The Search for the Oncogene, Houghton Mifflin Company, pp. 394, Boston.
• Barbacid, M., 1987, ras GENES, Ann. Rev. Biochem., 56: 779-827.
• Doolittle, W.F., 1999, Phylogenetic Classification and the Universal Tree, Science, 284: 2124-2128.
• Foury, F., 1997, Human genetic diseases: a cross-talk between man and yeast, Gene, 195: 1-10.
• Kataoka, T., Powers, S., et al., 1985, Functional Homology of Mammalian and Yeast RAS Genes, Cell, 40: 19-26.
• Kerem, B., Rommens, J.M., et al., 1989, Identification of the Cystic Fibrosis Gene: Genetic Analysis, Science, 245: 1073-1080.
• Ochman, H., Lawrence, J.G., Groisman, E.A., 2000, Lateral gene transfer and the nature of bacterial innovation, Nature, 405: 299-304.
• Pandey, A. and Lewitter, F., 1999, Nucleotide sequence databases: a gold mine for biologists, Trends in Biochemical Sciences, July, 276-280.
• Powers, S., Kataoka, T., et al., 1984, Genes in S. cerevisiae Encoding Proteins with Domains Homologous to the Mammalian ras Proteins, Cell, 36: 607-612.
• Riordan, J.R., Rommens, J.M., et al., 1989, Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA, Science, 245: 1066-1073.
• Rommens, J.M., Iannuzzi, M.C., et al., 1989, Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping, Science, 245: 1059-1065.
• Spector, D.H., Varmus, H.E., Bishop, J.M., 1978, Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates, Proc. Natl. Acad. Sci., 75: 4102-4106.
• Stehelin, D., Varmus, H.E., Bishop, J.M., Vogt, P.K., 1976, DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA, Nature, 260: 170-173.
• Fallows, James, The Political Scientist, The New Yorker, June 7, 1999.
• Anonymous, Biography of Dr. Harold Varmus, http://www.mskcc.org.
• autobiography at http://www.nobel.se
• autobiography from UCSF website (same autobio at Nobel site)
• Malaspina, Rick, New chancellor named for UC San Francisco, February 16, 1998, University of California, Santa Cruz Currents
• http://www.ucsc.edu/oncampus/97-98/02-16/ucsf.html.
• US Department of Health and Human Services, "Curiosity is the Key to Discovery: The Story of How Nobel Laureates Entered the World of Science," 1992.